Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC2812035 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Chen Zheng Z Li Zhengzheng Z Wei Bin B Yin Wenxuan W Xu Tao T Kotlikoff Michael I MI Ji Guangju G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20091005 2
FK506 binding protein 12.6 kDa (FKBP12.6), a protein that regulates ryanodine Ca(2+) release channels, may act as an important regulator of insulin secretion. In this study, the role of FKBP12.6 in the control of insulin secretion and blood glucose is clarified using FKBP12.6(-/-) mice. FKBP12.6(-/-) mice showed significant fed hyperinsulinemia but exhibited normoglycemia, fasting normoinsulinemia, and normal body weight compared with wild-type (WT) littermate control mice. Deletion of FKBP12.6 ...[more]