Ontology highlight
ABSTRACT:
SUBMITTER: Miura K
PROVIDER: S-EPMC2812124 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Miura Kenji K Yamashiro Hidenori H Uotani Kouichi K Kojima Satoshi S Yutsudo Takashi T Lu Jun J Yoshida Osamu O Yamano Yoshinori Y Maki Hideki H Arimoto Hirokazu H
Antimicrobial agents and chemotherapy 20091123 2
Van-M-02, a novel glycopeptide, was revealed to exert potent activities against Gram-positive bacteria, including vancomycin-resistant enterococci (VRE) and vancomycin-resistant Staphylococcus aureus (VRSA). A crude assay system was then used to study the mode of action of Van-M-02 as a peptidoglycan synthesis model of both vancomycin-susceptible and -resistant strains. The results suggested that Van-M-02 inhibits the synthesis of lipid intermediates irrespective of their termini. This inhibitor ...[more]