Ontology highlight
ABSTRACT:
SUBMITTER: Ribes S
PROVIDER: S-EPMC2812218 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Ribes Sandra S Ebert Sandra S Regen Tommy T Agarwal Amit A Tauber Simone C SC Czesnik Dirk D Spreer Annette A Bunkowski Stephanie S Eiffert Helmut H Hanisch Uwe-Karsten UK Hammerschmidt Sven S Nau Roland R
Infection and immunity 20091123 2
Toll-like receptors (TLRs) are crucial pattern recognition receptors in innate immunity that are expressed in microglia, the resident macrophages of the brain. TLR2, -4, and -9 are important in the responses against Streptococcus pneumoniae, the most common agent causing bacterial meningitis beyond the neonatal period. Murine microglial cultures were stimulated with agonists for TLR1/2 (Pam(3)CSK(4)), TLR4 (lipopolysaccharide), and TLR9 (CpG oligodeoxynucleotide) for 24 h and then exposed to eit ...[more]