Role of AKT kinase in measles virus replication.
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ABSTRACT:
SUBMITTER: Carsillo M
PROVIDER: S-EPMC2812387 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Role of AKT kinase in measles virus replication.
Carsillo Mary M Kim Dhohyung D Niewiesk Stefan S
Journal of virology 20091125 4
Many RNA and DNA viruses activate serine-threonine kinase AKT to increase virus replication. In contrast, measles virus (MV) infection leads to downregulation of AKT. This is thought to be beneficial for the virus because it correlates with immune suppression. To determine whether this is a sacrifice for the virus, we used a recombinant virus and transfected cells expressing constitutively active AKT and evaluated its effect on virus replication. In vitro, overexpression of AKT did not influence ...[more]
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