Ontology highlight
ABSTRACT:
SUBMITTER: Oliveira CC
PROVIDER: S-EPMC2812552 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Oliveira Cláudia C CC van Veelen Peter A PA Querido Bianca B de Ru Arnoud A Sluijter Marjolein M Laban Sandra S Drijfhout Jan W JW van der Burg Sjoerd H SH Offringa Rienk R van Hall Thorbald T
The Journal of experimental medicine 20091228 1
The nonclassical major histocompatibility complex (MHC) Qa-1b accommodates monomorphic leader peptides and functions as a ligand for germ line receptors CD94/NKG2, which are expressed by natural killer cells and CD8+ T cells. We here describe that the conserved peptides are replaced by a novel peptide repertoire of surprising diversity as a result of impairments in the antigen-processing pathway. This novel peptide repertoire represents immunogenic neoantigens for CD8+ T cells, as we found that ...[more]