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Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility.

ABSTRACT: Disrupted ontogeny of forebrain inhibitory interneurons leads to neurological disorders, including epilepsy. Adult mice lacking the urokinase plasminogen activator receptor (Plaur) have decreased numbers of neocortical GABAergic interneurons and spontaneous seizures, attributed to a reduction of hepatocyte growth factor/scatter factor (HGF/SF). We report that by increasing endogenous HGF/SF concentration in the postnatal Plaur null mouse brain maintains the interneuron populations in the adult, reverses the seizure behavior and stabilizes the spontaneous electroencephalogram activity. The perinatal intervention provides a pathway to reverse potential birth defects and ameliorate seizures in the adult.

SUBMITTER: Bae MH

PROVIDER: S-EPMC2812579 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility.

Bae Mihyun H MH Bissonette Gregory B GB Mars Wendy M WM Michalopoulos George K GK Achim Cristian L CL Depireux Didier A DA Powell Elizabeth M EM

Experimental neurology 20091022 1

Disrupted ontogeny of forebrain inhibitory interneurons leads to neurological disorders, including epilepsy. Adult mice lacking the urokinase plasminogen activator receptor (Plaur) have decreased numbers of neocortical GABAergic interneurons and spontaneous seizures, attributed to a reduction of hepatocyte growth factor/scatter factor (HGF/SF). We report that by increasing endogenous HGF/SF concentration in the postnatal Plaur null mouse brain maintains the interneuron populations in the adult, ...[more]

PMID: 19853606

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