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Caloric restriction delays disease onset and mortality in rhesus monkeys.

ABSTRACT: Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.

SUBMITTER: Colman RJ

PROVIDER: S-EPMC2812811 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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Caloric restriction delays disease onset and mortality in rhesus monkeys.

Colman Ricki J RJ Anderson Rozalyn M RM Johnson Sterling C SC Kastman Erik K EK Kosmatka Kristopher J KJ Beasley T Mark TM Allison David B DB Cruzen Christina C Simmons Heather A HA Kemnitz Joseph W JW Weindruch Richard R

Science (New York, N.Y.) 20090701 5937

Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths ...[more]

PMID: 19590001

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