Ontology highlight
ABSTRACT:
SUBMITTER: McBride AJ
PROVIDER: S-EPMC2812920 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
McBride Alan J A AJ Cerqueira Gustavo M GM Suchard Marc A MA Moreira Angela N AN Zuerner Richard L RL Reis Mitermayer G MG Haake David A DA Ko Albert I AI Dellagostin Odir A OA
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20081106 2
Recent serologic, immunoprotection, and pathogenesis studies identified the Lig proteins as key virulence determinants in interactions of leptospiral pathogens with the mammalian host. We examined the sequence variation and recombination patterns of ligA, ligB, and ligC among 10 pathogenic strains from five Leptospira species. All strains were found to have intact ligB genes and genetic drift accounting for most of the ligB genetic diversity observed. The ligA gene was found exclusively in L. in ...[more]