Noncoding RNA of glutamine synthetase I modulates antibiotic production in Streptomyces coelicolor A3(2).
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ABSTRACT:
SUBMITTER: D'Alia D
PROVIDER: S-EPMC2812974 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Noncoding RNA of glutamine synthetase I modulates antibiotic production in Streptomyces coelicolor A3(2).
D'Alia Davide D Nieselt Kay K Steigele Stephan S Müller Jonas J Verburg Ilse I Takano Eriko E
Journal of bacteriology 20091204 4
Overexpression of antisense chromosomal cis-encoded noncoding RNAss (ncRNAs) in glutamine synthetase I resulted in a decrease in growth, protein synthesis, and antibiotic production in Streptomyces coelicolor. In addition, we predicted 3,597 cis-encoded ncRNAs and validated 13 of them experimentally, including several ncRNAs that are differentially expressed in bacterial hormone-defective mutants. ...[more]
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