Ontology highlight
ABSTRACT:
SUBMITTER: Dayhoff JE
PROVIDER: S-EPMC2813322 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Dayhoff Judith E JE Shoemaker Benjamin A BA Bryant Stephen H SH Panchenko Anna R AR
Journal of molecular biology 20091030 4
The evolution of protein interactions cannot be deciphered without a detailed analysis of interaction interfaces and binding modes. We performed a large-scale study of protein homooligomers in terms of their symmetry, interface sizes, and conservation of binding modes. We also focused specifically on the evolution of protein binding modes from nine families of homooligomers and mapped 60 different binding modes and oligomerization states onto the phylogenetic trees of these families. We observed ...[more]