Bayesian network analysis of targeting interactions in chromatin.
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ABSTRACT:
SUBMITTER: van Steensel B
PROVIDER: S-EPMC2813475 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Bayesian network analysis of targeting interactions in chromatin.
van Steensel Bas B Braunschweig Ulrich U Filion Guillaume J GJ Chen Menzies M van Bemmel Joke G JG Ideker Trey T
Genome research 20091209 2
In eukaryotes, many chromatin proteins together regulate gene expression. Chromatin proteins often direct the genomic binding pattern of other chromatin proteins, for example, by recruitment or competition mechanisms. The network of such targeting interactions in chromatin is complex and still poorly understood. Based on genome-wide binding maps, we constructed a Bayesian network model of the targeting interactions among a broad set of 43 chromatin components in Drosophila cells. This model pred ...[more]
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