Ontology highlight
ABSTRACT:
SUBMITTER: Visser Smit GD
PROVIDER: S-EPMC2813709 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Visser Smit Gina D GD Place Trenton L TL Cole Sara L SL Clausen Kathryn A KA Vemuganti Soumya S Zhang Guojuan G Koland John G JG Lill Nancy L NL
Science signaling 20091222 102
Amino acid residues 1 to 434 of the E3 ubiquitin ligase Cbl control signaling of the epidermal growth factor receptor (EGFR) by enhancing its ubiquitination, down-regulation, and lysosomal degradation. This region of Cbl comprises a tyrosine kinase-binding domain, a linker region, a really interesting new gene finger (RF), and a subset of the residues of the RF tail. In experiments with full-length alanine substitution mutants, we demonstrated that the RF tail of Cbl regulated biochemically dist ...[more]