Global effects of BKV infection on gene expression in human primary kidney epithelial cells.
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ABSTRACT:
SUBMITTER: Abend JR
PROVIDER: S-EPMC2813893 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
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Global effects of BKV infection on gene expression in human primary kidney epithelial cells.
Abend Johanna R JR Low Jonathan A JA Imperiale Michael J MJ
Virology 20091128 1
BK virus (BKV) is a ubiquitous human pathogen that establishes a lifelong persistent infection in kidney epithelial cells. BKV reactivation within these cells results in a lytic infection in immunocompromised patients. Little is known about the specific interactions of BKV and the host cell during persistence and reactivation. We performed global cellular gene expression analyses using microarrays to characterize the global effect of BKV on primary kidney epithelial cells during the viral life c ...[more]
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