Ontology highlight
ABSTRACT:
SUBMITTER: Nagrath D
PROVIDER: S-EPMC2814076 | biostudies-literature | 2009 Jul-Sep
REPOSITORIES: biostudies-literature
Nagrath Deepak D Xu Hongzhi H Tanimura Yoko Y Zuo Rongjun R Berthiaume François F Avila Marco M Yarmush Rubin R Yarmush Martin L ML
Metabolic engineering 20090607 4-5
Fatty liver is a significant risk factor for liver transplantation, and accounts for nearly half of the livers rejected from the donor pool. We hypothesized that metabolic preconditioning via ex vivo perfusion of the liver graft can reduce fat content and increase post-transplant survival to an acceptable range. We describe a perfusate medium containing agents that promote the defatting of hepatocytes and explanted livers. Defatting agents were screened on cultured hepatocytes made fatty by pre- ...[more]