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ABSTRACT:
SUBMITTER: Moskalenko AV
PROVIDER: S-EPMC2814202 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Moskalenko Andriy V AV Yarova Polina L PL Gordeev Sergey N SN Smirnov Sergey V SV
Biophysical journal 20100201 3
Understanding the structural organization and distribution of proteins in biological cells is of fundamental importance in biomedical research. The use of conventional fluorescent microscopy for this purpose is limited due to its relatively low spatial resolution compared to the size of a single protein molecule. Atomic force microscopy (AFM), on the other hand, allows one to achieve single-protein resolution by scanning the cell surface using a specialized ligand-coated AFM tip. However, becaus ...[more]