Ontology highlight
ABSTRACT:
SUBMITTER: McGlinchey RP
PROVIDER: S-EPMC2814216 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
McGlinchey Ryan P RP Nett Markus M Eustáquio Alessandra S AS Asolkar Ratnakar N RN Fenical William W Moore Bradley S BS
Journal of the American Chemical Society 20080531 25
A new shunt in the phenylalanine biosynthetic pathway to the nonproteinogenic amino acid L-3-cyclohex-2'-enylalanine was exploited in the marine bacterium Salinispora tropica by mutagenesis to allow for the genetic engineering of unnatural derivatives of the potent proteasome inhibitor salinosporamide A (2) such as antiprotealide (1). ...[more]