Ontology highlight
ABSTRACT:
SUBMITTER: Corzett TH
PROVIDER: S-EPMC2814230 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Corzett Todd H TH Fodor Imola K IK Choi Megan W MW Walsworth Vicki L VL Turteltaub Kenneth W KW McCutchen-Maloney Sandra L SL Chromy Brett A BA
Journal of biomedicine & biotechnology 20100114
Quantifying the variation in the human plasma proteome is an essential prerequisite for disease-specific biomarker detection. We report here on the longitudinal and individual variation in human plasma characterized by two-dimensional difference gel electrophoresis (2-D DIGE) using plasma samples from eleven healthy subjects collected three times over a two week period. Fixed-effects modeling was used to remove dye and gel variability. Mixed-effects modeling was then used to quantitate the sourc ...[more]