Ontology highlight
ABSTRACT:
SUBMITTER: Tomaszewski M
PROVIDER: S-EPMC2814817 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Tomaszewski Maciej M Charchar Fadi J FJ Barnes Timothy T Gawron-Kiszka Magdalena M Sedkowska Agnieszka A Podolecka Ewa E Kowalczyk Jacek J Rathbone Wendy W Kalarus Zbigniew Z Grzeszczak Wladyslaw W Goodall Alison H AH Samani Nilesh J NJ Zukowska-Szczechowska Ewa E
Arteriosclerosis, thrombosis, and vascular biology 20090810 9
<h4>Objective</h4>A rare mutation in low-density lipoprotein receptor-related protein 6 gene (LRP6) was identified as the primary molecular defect underlying monogenic form of coronary artery disease. We hypothesized that common variants in LRP6 could predispose subjects to elevated LDL-cholesterol (LDL-C).<h4>Methods and results</h4>Twelve common (minor allele frequency > or =0.1) single nucleotide polymorphisms in LRP6 were genotyped in 703 individuals from 213 Polish pedigrees (Silesian Cardi ...[more]