Ontology highlight
ABSTRACT:
SUBMITTER: Oldenhove G
PROVIDER: S-EPMC2814877 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Oldenhove Guillaume G Bouladoux Nicolas N Wohlfert Elizabeth A EA Hall Jason A JA Chou David D Dos Santos Liliane L O'Brien Shaun S Blank Rebecca R Lamb Erika E Natarajan Sundar S Kastenmayer Robin R Hunter Christopher C Grigg Michael E ME Belkaid Yasmine Y
Immunity 20091105 5
Using a model of lethal oral infection with Toxoplasma gondii, we examined the fate of both induced and natural regulatory T (Treg) cells in the face of strong inflammatory responses occurring in a tolerogenic-prone environment. We found that during highly T helper 1 (Th1) cell-polarized mucosal immune responses, Treg cell numbers collapsed via multiple pathways, including blockade of Treg cell induction and disruption of endogenous Treg cell homeostasis. In particular, shutdown of interleukin 2 ...[more]