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A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia.

ABSTRACT: Murine models of disease are vital to the understanding of pathogenesis and the development of novel therapeutics. We have previously established interleukin (IL)-15 transgenic (tg) mice that demonstrate rapid proliferation of natural killer (NK) and T cells, followed by spontaneous transformation to lethal leukemia. Herein, we have characterized this model, which has many features in common with the aggressive variants of NK and T large granular lymphocyte leukemia (LGLL) in humans. The LGLL blasts are cytolytic and produce IFN-gammaex vivo. Cytogenetic analysis revealed trisomy of chromosome 17 and/or 15. This model should provide opportunities to develop effective standard therapies for this fatal disease.

SUBMITTER: Yokohama A

PROVIDER: S-EPMC2814907 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia.

Yokohama Akihiko A Mishra Anjali A Mitsui Takeki T Becknell Brian B Johns Jessica J Curphey Douglas D Blaser Bradley W BW Vandeusen Jeffrey B JB Mao Hsiaoyin H Yu Jianhua J Caligiuri Michael A MA

Leukemia research 20090805 2

Murine models of disease are vital to the understanding of pathogenesis and the development of novel therapeutics. We have previously established interleukin (IL)-15 transgenic (tg) mice that demonstrate rapid proliferation of natural killer (NK) and T cells, followed by spontaneous transformation to lethal leukemia. Herein, we have characterized this model, which has many features in common with the aggressive variants of NK and T large granular lymphocyte leukemia (LGLL) in humans. The LGLL bl ...[more]

PMID: 19660811

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