The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi.
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ABSTRACT:
SUBMITTER: Hartkamp J
PROVIDER: S-EPMC2815029 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi.
Hartkamp Jörg J Carpenter Brian B Roberts Stefan G E SG
Molecular cell 20100101 2
The Wilms' tumor suppressor protein WT1 functions as a transcriptional regulator of genes controlling growth, apoptosis, and differentiation. It has become clear that WT1 can act as an oncogene in many tumors, primarily through the inhibition of apoptosis. Here, we identify the serine protease HtrA2 as a WT1 binding partner and find that it cleaves WT1 at multiple sites following the treatment of cells with cytotoxic drugs. Ablation of HtrA2 activity either by chemical inhibitor or by siRNA prev ...[more]
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