Ontology highlight
ABSTRACT:
SUBMITTER: Lei X
PROVIDER: S-EPMC2815189 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Lei Xiufen X Bai Zhiqiang Z Ye Fengchun F Xie Jianping J Kim Chan-Gil CG Huang Yufei Y Gao Shou-Jiang SJ
Nature cell biology 20100117 2
Kaposi's sarcoma-associated herpesvirus (KSHV) is causally linked to several acquired immune deficiency syndrome-related malignancies, including Kaposi's sarcoma, primary effusion lymphoma (PEL) and a subset of multicentric Castleman's disease. Control of viral lytic replication is essential for KSHV latency, evasion of the host immune system and induction of tumours. Here, we show that deletion of a 14 microRNA (miRNA) cluster from the KSHV genome significantly enhances viral lytic replication ...[more]