Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.
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ABSTRACT:
SUBMITTER: Waskar M
PROVIDER: S-EPMC2815744 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
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Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.
Waskar Morris M Landis Gary N GN Shen Jie J Curtis Christina C Tozer Kevin K Abdueva Diana D Skvortsov Dmitriy D Tavaré Simon S Tower John J
Aging 20091027 11
Truncated and mutant forms ofp53 affect life span in Drosophila, nematodes and mice, however the role of wild-type p53 in aging remains unclear. Here conditional over-expression of both wild-type and mutant p53 transgenes indicated that, in adult flies, p53 limits life span in females but favors life span in males. In contrast, during larval development, moderate over-expression of p53 produced both male and female adults with increased life span. Mutations of the endogenous p53 gene also had se ...[more]
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