Ontology highlight
ABSTRACT:
SUBMITTER: Postma L
PROVIDER: S-EPMC2815748 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Postma Lucie L Lehrach Hans H Ralser Markus M
Aging 20091204 11
Metabolic activity generates oxidizing molecules throughout life, but it is still debated if the resulting damage of macromolecules is a causality, or consequence, of the aging process. This problem demands for studying growth- and longevity phenotypes separately. Here, we assayed a complete collection of haploid Saccharomyces cerevisiae knock-out strains for their capacity to endure long periods at low metabolic rates. Deletion of 93 genes, predominantly factors of primary metabolism, allowed y ...[more]