Ontology highlight
ABSTRACT:
SUBMITTER: Mauvezin C
PROVIDER: S-EPMC2816618 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Mauvezin Caroline C Orpinell Meritxell M Francis Víctor A VA Mansilla Francisco F Duran Jordi J Ribas Vicent V Palacín Manuel M Boya Patricia P Teleman Aurelio A AA Zorzano Antonio A
EMBO reports 20091204 1
The regulation of autophagy in metazoans is only partly understood, and there is a need to identify the proteins that control this process. The diabetes- and obesity-regulated gene (DOR), a recently reported nuclear cofactor of thyroid hormone receptors, is expressed abundantly in metabolically active tissues such as muscle. Here, we show that DOR shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. W ...[more]