Fractionated subcutaneous rituximab is well-tolerated and preserves CD20 expression on tumor cells in patients with chronic lymphocytic leukemia.
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ABSTRACT:
SUBMITTER: Aue G
PROVIDER: S-EPMC2817038 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
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Fractionated subcutaneous rituximab is well-tolerated and preserves CD20 expression on tumor cells in patients with chronic lymphocytic leukemia.
Aue Georg G Lindorfer Margaret A MA Beum Paul V PV Pawluczkowycz Andrew W AW Vire Berengere B Hughes Thomas T Taylor Ronald P RP Wiestner Adrian A
Haematologica 20090813 2
A pilot study previously demonstrated that thrice-weekly, fractionated-dose intravenous rituximab (RTX) limits CD20 loss from chronic lymphocytic leukemia (CLL) B cells, thereby enhancing immunotherapeutic targeting. Here, we investigated the feasibility of giving 20 mg rituximab subcutaneously thrice weekly for up to 12 weeks in 4 previously treated CLL patients. Subcutaneous rituximab was well-tolerated with minimal injection site reactions; a variable degree of efficacy was observed, likely i ...[more]
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