Ontology highlight
ABSTRACT:
SUBMITTER: Marcoux V
PROVIDER: S-EPMC2817373 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Marcoux Veronica V Wei Guojian G Tabel Henry H Bull Harold J HJ
Journal of biomedicine & biotechnology 20100120
Trypanosomes encode a family of proteins known as Major Surface Metalloproteases (MSPs). We have identified six putative MSPs encoded within the partially sequenced T. congolense genome. Phylogenic analysis indicates that T. congolense MSPs belong to five subfamilies that are conserved among African trypanosome species. Molecular modeling, based on the known structure of Leishmania Major GP63, reveals subfamily-specific structural variations around the putative active site despite conservation o ...[more]