Ontology highlight
ABSTRACT:
SUBMITTER: Wu JY
PROVIDER: S-EPMC2817460 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Wu John Y JY Stone Michael D MD Zhuang Xiaowei X
Nucleic acids research 20091117 3
The activity of the telomerase ribonucleoprotein enzyme is essential for the maintenance of genome stability and normal cell development. Despite the biomedical importance of telomerase activity, detailed structural models for the enzyme remain to be established. Here we report a single-molecule assay for direct structural analysis of catalytically active telomerase enzymes. In this assay, oligonucleotide hybridization was used to probe the primer-extension activity of individual telomerase enzy ...[more]