Ontology highlight
ABSTRACT:
SUBMITTER: Grossberg AJ
PROVIDER: S-EPMC2817620 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Grossberg Aaron J AJ Scarlett Jarrad M JM Zhu XinXia X Bowe Darren D DD Batra Ayesha K AK Braun Theodore P TP Marks Daniel L DL
Endocrinology 20091216 2
The proinflammatory cytokine leukemia inhibitory factor (LIF) is induced in disease states and is known to inhibit food intake when administered centrally. However, the neural pathways underlying this effect are not well understood. We demonstrate that LIF acutely inhibits food intake by directly activating pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus. We show that arcuate POMC neurons express the LIF-R, and that LIF stimulates the release of the anorexigenic pe ...[more]