Ontology highlight
ABSTRACT:
SUBMITTER: Rose MF
PROVIDER: S-EPMC2818435 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Rose Matthew F MF Ren Jun J Ahmad Kaashif A KA Chao Hsiao-Tuan HT Klisch Tiemo J TJ Flora Adriano A Greer John J JJ Zoghbi Huda Y HY
Neuron 20091101 3
Mice lacking the proneural transcription factor Math1 (Atoh1) lack multiple neurons of the proprioceptive and arousal systems and die shortly after birth from an apparent inability to initiate respiration. We sought to determine whether Math1 was necessary for the development of hindbrain nuclei involved in respiratory rhythm generation, such as the parafacial respiratory group/retrotrapezoid nucleus (pFRG/RTN), defects in which are associated with congenital central hypoventilation syndrome (CC ...[more]