Early Parkinson's disease: longitudinal changes in brain activity during sequence learning.
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ABSTRACT:
SUBMITTER: Carbon M
PROVIDER: S-EPMC2818462 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Early Parkinson's disease: longitudinal changes in brain activity during sequence learning.
Carbon Maren M Reetz Kathrin K Ghilardi M Felice MF Dhawan Vijay V Eidelberg David D
Neurobiology of disease 20091110 2
Impairment of sequence learning is common in Parkinson's disease (PD), but the time course of this cognitive abnormality is not known. We assessed longitudinal changes in sequence learning performance and associated task-related cerebral blood flow in 13 early stage PD patients who underwent H(2)(15)O PET at baseline and again 2 years later. Ten healthy volunteer subjects served as controls. A trend toward decline in learning performance (p=0.08) was evident over the 2 years of follow-up. During ...[more]
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