Ontology highlight
ABSTRACT:
SUBMITTER: Mishra SK
PROVIDER: S-EPMC2818468 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Mishra Santosh K SK Hoon Mark A MA
Molecular and cellular neurosciences 20091021 1
Here we make use of neural ablation to investigate the properties of the TrpV1-expressing neurons in the trigeminal and dorsal root ganglia of mice. Resiniferotoxin (RTX), a potent TrpV1 agonist, administered either by direct injection in the ganglion or intrathecally killed approximately 70% of TrpV1 cells and resulted in modest thermal analgesia. Interestingly, after carageenan injection in the hind paw, the analgesic effects of RTX were dramatically increased with mice now paradoxically showi ...[more]