Ontology highlight
ABSTRACT:
SUBMITTER: Stanika RI
PROVIDER: S-EPMC2818520 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Stanika Ruslan I RI Winters Christine A CA Pivovarova Natalia B NB Andrews S Brian SB
Neurobiology of disease 20091029 2
Hippocampal CA1 pyramidal neurons are selectively vulnerable to ischemia, while adjacent CA3 neurons are relatively resistant. Although glutamate receptor-mediated mitochondrial Ca(2+) overload and dysfunction is a major component of ischemia-induced neuronal death, no direct relationship between selective neuronal vulnerability and mitochondrial dysfunction has been demonstrated in intact brain preparations. Here, we show that in organotypic slice cultures NMDA induces much larger Ca(2+) elevat ...[more]