Ontology highlight
ABSTRACT:
SUBMITTER: Hardcastle J
PROVIDER: S-EPMC2818668 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Hardcastle Jayson J Kurozumi Kazuhiko K Dmitrieva Nina N Sayers Martin P MP Ahmad Sarwat S Waterman Peter P Weissleder Ralph R Chiocca E Antonio EA Kaur Balveen B
Molecular therapy : the journal of the American Society of Gene Therapy 20091020 2
Oncolytic viral (OV) therapy is a promising therapeutic modality for brain tumors. Vasculostatin (Vstat120) is the cleaved and secreted extracellular fragment of brain-specific angiogenesis inhibitor 1 (BAI1), a brain-specific receptor. To date, the therapeutic efficacy of Vstat120 delivery into established tumors has not been investigated. Here we tested the therapeutic efficacy of combining Vstat120 gene delivery in conjunction with OV therapy. We constructed RAMBO (Rapid Antiangiogenesis Medi ...[more]