A neural mechanism for exacerbation of headache by light.
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ABSTRACT:
SUBMITTER: Noseda R
PROVIDER: S-EPMC2818758 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
A neural mechanism for exacerbation of headache by light.
Noseda Rodrigo R Kainz Vanessa V Jakubowski Moshe M Gooley Joshua J JJ Saper Clifford B CB Digre Kathleen K Burstein Rami R
Nature neuroscience 20100110 2
The perception of migraine headache, which is mediated by nociceptive signals transmitted from the cranial dura mater to the brain, is uniquely exacerbated by exposure to light. We found that exacerbation of migraine headache by light is prevalent among blind individuals who maintain non-image-forming photoregulation in the face of massive rod/cone degeneration. Using single-unit recording and neural tract tracing in the rat, we identified dura-sensitive neurons in the posterior thalamus whose a ...[more]
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