Unknown

Dataset Information

0

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.


ABSTRACT: The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively. Gene signatures of normal brain cell types show a strong relationship between subtypes and different neural lineages. Additionally, response to aggressive therapy differs by subtype, with the greatest benefit in the Classical subtype and no benefit in the Proneural subtype. We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.

SUBMITTER: Verhaak RG 

PROVIDER: S-EPMC2818769 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.

Verhaak Roel G W RG   Hoadley Katherine A KA   Purdom Elizabeth E   Wang Victoria V   Qi Yuan Y   Wilkerson Matthew D MD   Miller C Ryan CR   Ding Li L   Golub Todd T   Mesirov Jill P JP   Alexe Gabriele G   Lawrence Michael M   O'Kelly Michael M   Tamayo Pablo P   Weir Barbara A BA   Gabriel Stacey S   Winckler Wendy W   Gupta Supriya S   Jakkula Lakshmi L   Feiler Heidi S HS   Hodgson J Graeme JG   James C David CD   Sarkaria Jann N JN   Brennan Cameron C   Kahn Ari A   Spellman Paul T PT   Wilson Richard K RK   Speed Terence P TP   Gray Joe W JW   Meyerson Matthew M   Getz Gad G   Perou Charles M CM   Hayes D Neil DN  

Cancer cell 20100101 1


The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively.  ...[more]

Similar Datasets

| S-EPMC5039391 | biostudies-literature
| S-EPMC4526352 | biostudies-literature
| S-EPMC5567352 | biostudies-literature
| S-EPMC10589377 | biostudies-literature
| S-EPMC321763 | biostudies-literature
| S-EPMC10153188 | biostudies-literature
| S-EPMC5426990 | biostudies-literature
2015-03-04 | E-GEOD-40774 | biostudies-arrayexpress
2015-03-04 | GSE40774 | GEO
| S-EPMC4693300 | biostudies-literature