Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC2818795 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Xu Yanhui Y Chen Yu Y Zhang Ping P Jeffrey Philip D PD Shi Yigong Y
Molecular cell 20080901 6
Protein phosphatase 2A (PP2A) regulates many essential aspects of cellular physiology. Members of the regulatory B/B55/PR55 family are thought to play a key role in the dephosphorylation of Tau, whose hyperphosphorylation contributes to Alzheimer's disease. The underlying mechanisms of the PP2A-Tau connection remain largely enigmatic. Here, we report the complete reconstitution of a Tau dephosphorylation assay and the crystal structure of a heterotrimeric PP2A holoenzyme involving the regulatory ...[more]