Ontology highlight
ABSTRACT:
SUBMITTER: Terai K
PROVIDER: S-EPMC2818832 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Terai Kenta K Abbas Tarek T Jazaeri Amir A AA Dutta Anindya A
Molecular cell 20100101 1
Monoubiquitination of proliferating cell nuclear antigen (PCNA) is a critical posttranslational modification essential for DNA repair by translesion DNA synthesis (TLS). The Rad18 E3 ubiquitin ligase cooperates with the E2 Rad6 to monoubiquitinate PCNA in response to DNA damage. How PCNA is monoubiquitinated in unperturbed cells and whether this plays a role in the repair of DNA associated with replication is not known. We show that the CRL4(Cdt2) E3 ubiquitin ligase complex promotes PCNA monoub ...[more]