Ontology highlight
ABSTRACT:
SUBMITTER: Mendoza-Ferri MG
PROVIDER: S-EPMC2819033 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Mendoza-Ferri Maria G MG Hartinger Christian G CG Mendoza Marco A MA Groessl Michael M Egger Alexander E AE Eichinger Rene E RE Mangrum John B JB Farrell Nicholas P NP Maruszak Magdalena M Bednarski Patrick J PJ Klein Franz F Jakupec Michael A MA Nazarov Alexey A AA Severin Kay K Keppler Bernhard K BK
Journal of medicinal chemistry 20090201 4
Multinuclear platinum anticancer complexes are a proven option to overcome resistance of established anticancer compounds. Transferring this concept to ruthenium complexes led to the synthesis of dinuclear Ru(II)-arene compounds containing a bis(pyridinone)alkane ligand linker. A pronounced influence of the spacer length on the in vitro anticancer activity was found, which is correlated to the lipophilicity of the complexes. IC(50) values in the same dimension as for established platinum drugs w ...[more]