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Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons.


ABSTRACT: Ablation of preBötzinger complex (preBötC) neurons, critical for respiratory rhythm generation, resulted in a progressive, increasingly severe disruption of respiratory pattern, initially during sleep and then also during wakefulness in adult rats. Sleep-disordered breathing is highly prevalent in elderly humans and in some patients with neurodegenerative disease. We propose that sleep-disordered breathing results from loss of preBötC neurons and could underlie death during sleep in these populations.

SUBMITTER: McKay LC 

PROVIDER: S-EPMC2819071 | biostudies-literature |

REPOSITORIES: biostudies-literature

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