Ontology highlight
ABSTRACT:
SUBMITTER: Delaney C
PROVIDER: S-EPMC2819359 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Delaney Colleen C Heimfeld Shelly S Brashem-Stein Carolyn C Voorhies Howard H Manger Ronald L RL Bernstein Irwin D ID
Nature medicine 20100117 2
Delayed myeloid engraftment after cord blood transplantation (CBT) is thought to result from inadequate numbers of progenitor cells in the graft and is associated with increased early transplant-related morbidity and mortality. New culture strategies that increase the number of cord blood progenitors capable of rapid myeloid engraftment after CBT would allow more widespread use of this stem cell source for transplantation. Here we report the development of a clinically relevant Notch-mediated ex ...[more]