Ontology highlight
ABSTRACT:
SUBMITTER: Guo J
PROVIDER: S-EPMC2819982 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Guo Jun J Liu Minlin M Yang Dehong D Bouxsein Mary L ML Saito Hiroaki H Galvin R J Sells RJ Kuhstoss Stuart A SA Thomas Clare C CC Schipani Ernestina E Baron Roland R Bringhurst F Richard FR Kronenberg Henry M HM
Cell metabolism 20100201 2
Parathyroid hormone (PTH) suppresses Dickkopf 1 (Dkk1) expression in osteoblasts. To determine whether this suppression is essential for PTH-mediated Wnt signaling and bone formation, we examined mice that overexpress Dkk1 in osteoblasts (Dkk1 mice). Dkk1 mice were osteopenic due to abnormal osteoblast and osteoclast activity. When fed a low-calcium diet, and in two other models of hyperparathyroidism, these mice failed to develop the peritrabecular stromal cell response ("osteitis fibrosis") an ...[more]