Ontology highlight
ABSTRACT:
SUBMITTER: Borisova SA
PROVIDER: S-EPMC2819989 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Borisova Svetlana A SA Circello Benjamin T BT Zhang Jun Kai JK van der Donk Wilfred A WA Metcalf William W WW
Chemistry & biology 20100101 1
Rhizocticins are phosphonate oligopeptide antibiotics containing the C-terminal nonproteinogenic amino acid (Z)-l-2-amino-5-phosphono-3-pentenoic acid (APPA). Here we report the identification and characterization of the rhizocticin biosynthetic gene cluster (rhi) in Bacillus subtilis ATCC6633. Rhizocticin B was heterologously produced in the nonproducer strain Bacillus subtilis 168. A biosynthetic pathway is proposed on the basis of bioinformatics analysis of the rhi genes. One of the steps dur ...[more]