Ontology highlight
ABSTRACT:
SUBMITTER: Wallace C
PROVIDER: S-EPMC2820243 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Wallace Chris C Smyth Deborah J DJ Maisuria-Armer Meeta M Walker Neil M NM Todd John A JA Clayton David G DG
Nature genetics 20091206 1
Genome-wide association (GWA) studies to map common disease susceptibility loci have been hugely successful, with over 300 reproducibly associated loci reported to date. However, these studies have not yet provided convincing evidence for any susceptibility locus subject to parent-of-origin effects. Using imputation to extend existing GWA datasets, we have obtained robust evidence at rs941576 for paternally inherited risk of type 1 diabetes (T1D; ratio of allelic effects for paternal versus mate ...[more]