Drug focus: Pharmacogenetic studies related to cyclophosphamide-based therapy.
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ABSTRACT:
SUBMITTER: Pinto N
PROVIDER: S-EPMC2820268 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Drug focus: Pharmacogenetic studies related to cyclophosphamide-based therapy.
Pinto Navin N Ludeman Susan M SM Dolan M Eileen ME
Pharmacogenomics 20091201 12
Cyclophosphamide is a cornerstone in the treatment of many pediatric and adult malignancies, as well as in the treatment of refractory autoimmune conditions. Genetic factors are thought to play a role in the interindividual variation in both response and toxicities associated with cyclophosphamide-based therapies. This drug focus reviews the most compelling studies conducted on the pharmacogenetics of cyclophosphamide-based therapies. Broader pharmacogenomic studies are needed and may reveal add ...[more]
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