Ontology highlight
ABSTRACT:
SUBMITTER: Kulik L
PROVIDER: S-EPMC2820395 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Kulik Liudmila L Fleming Sherry D SD Moratz Chantal C Reuter Jason W JW Novikov Aleksey A Chen Kuan K Andrews Kathy A KA Markaryan Adam A Quigg Richard J RJ Silverman Gregg J GJ Tsokos George C GC Holers V Michael VM
Journal of immunology (Baltimore, Md. : 1950) 20090501 9
Intestinal ischemia-reperfusion (IR) injury is initiated when natural IgM Abs recognize neo-epitopes that are revealed on ischemic cells. The target molecules and mechanisms whereby these neo-epitopes become accessible to recognition are not well understood. Proposing that isolated intestinal epithelial cells (IEC) may carry IR-related neo-epitopes, we used in vitro IEC binding assays to screen hybridomas created from B cells of unmanipulated wild-type C57BL/6 mice. We identified a novel IgM mAb ...[more]