Ontology highlight
ABSTRACT:
SUBMITTER: Haq I
PROVIDER: S-EPMC2820470 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Haq Imran I Chappell Sally S Johnson Simon R SR Lotya Juzer J Daly Leslie L Morgan Kevin K Guetta-Baranes Tamar T Roca Josep J Rabinovich Roberto R Millar Ann B AB Donnelly Seamas C SC Keatings Vera V MacNee William W Stolk Jan J Hiemstra Pieter S PS Miniati Massimo M Monti Simonetta S O'Connor Clare M CM Kalsheker Noor N
BMC medical genetics 20100115
<h4>Background</h4>Genetic factors play a role in chronic obstructive pulmonary disease (COPD) but are poorly understood. A number of candidate genes have been proposed on the basis of the pathogenesis of COPD. These include the matrix metalloproteinase (MMP) genes which play a role in tissue remodelling and fit in with the protease--antiprotease imbalance theory for the cause of COPD. Previous genetic studies of MMPs in COPD have had inadequate coverage of the genes, and have reported conflicti ...[more]