Nuclear pore proteins nup153 and megator define transcriptionally active regions in the Drosophila genome.

ABSTRACT: Transcriptional regulation is one of the most important processes for modulating gene expression. Though much of this control is attributed to transcription factors, histones, and associated enzymes, it is increasingly apparent that the spatial organization of chromosomes within the nucleus has a profound effect on transcriptional activity. Studies in yeast indicate that the nuclear pore complex might promote transcription by recruiting chromatin to the nuclear periphery. In higher eukaryotes, however, it is not known whether such regulation has global significance. Here we establish nucleoporins as a major class of global regulators for gene expression in Drosophila melanogaster. Using chromatin-immunoprecipitation combined with microarray hybridisation, we show that Nup153 and Megator (M

SUBMITTER: Vaquerizas JM 

PROVIDER: S-EPMC2820533 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature