Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors.
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ABSTRACT:
SUBMITTER: Selhuber-Unkel C
PROVIDER: S-EPMC2820634 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors.
Selhuber-Unkel C C Erdmann T T López-García M M Kessler H H Schwarz U S US Spatz J P JP
Biophysical journal 20100201 4
Spatial patterning of biochemical cues on the micro- and nanometer scale controls numerous cellular processes such as spreading, adhesion, migration, and proliferation. Using force microscopy we show that the lateral spacing of individual integrin receptor-ligand bonds determines the strength of cell adhesion. For spacings > or = 90 nm, focal contact formation was inhibited and the detachment forces as well as the stiffness of the cell body were significantly decreased compared to spacings < or ...[more]
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