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Immune response modeling of interferon beta-pretreated influenza virus-infected human dendritic cells.

ABSTRACT: The pretreatment of human dendritic cells with interferon-beta enhances their immune response to influenza virus infection. We measured the expression levels of several key players in that response over a period of 13 h both during pretreatment and after viral infection. Their activation profiles reflect the presence of both negative and positive feedback loops in interferon induction and interferon signaling pathway. Based on these measurements, we have developed a comprehensive computational model of cellular immune response that elucidates its mechanism and its dynamics in interferon-pretreated dendritic cells, and provides insights into the effects of duration and strength of pretreatment.

SUBMITTER: Qiao L

PROVIDER: S-EPMC2820658 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Immune response modeling of interferon beta-pretreated influenza virus-infected human dendritic cells.

Qiao Liang L Phipps-Yonas Hannah H Hartmann Boris B Moran Thomas M TM Sealfon Stuart C SC Hayot Fernand F

Biophysical journal 20100201 4

The pretreatment of human dendritic cells with interferon-beta enhances their immune response to influenza virus infection. We measured the expression levels of several key players in that response over a period of 13 h both during pretreatment and after viral infection. Their activation profiles reflect the presence of both negative and positive feedback loops in interferon induction and interferon signaling pathway. Based on these measurements, we have developed a comprehensive computational m ...[more]

PMID: 20159146

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